Description

Overview

CJC-1295 (No DAC) is a tetra-substituted GRF (1-29) analog that targets the GHRH receptors on pituitary cells, stimulating endogenous GH release. Four amino acid substitutions (positions 2, 8, 15, and 27) improve its resistance to degradation by enzymes like DPP-4. This allows for greater bioactivity despite a shorter duration of action compared to DAC-bound versions.

Chemical Makeup

Molecular Formula: C152H252N44O42

Molecular Weight: 3367.9 g/mol

Other Known Titles: CJC-1295 Without DAC

Pituitary Gland Mechanism

CJC-1295 (No DAC) binds to GHRH receptors on somatotroph cells in the pituitary, likely triggering conformational changes that activate G-proteins. This cascade may increase secondary messengers like cAMP, activating protein kinases that regulate gene expression. The result is enhanced GH synthesis and secretion, promoting anabolic and restorative physiological effects.

Growth Hormone Pulsatility

Research on modified GRF 1-29 indicates that CJC-1295 (No DAC) may elevate GH release by approximately 70–107% over 12 hours and increase IGF-1 by around 28%. These changes have been linked to enhanced skin thickness, collagen activity, and muscle hypertrophy in experimental models, reflecting its influence on the GH–IGF-1 axis.

Gastrointestinal Studies

Some experimental models suggest potential interactions between GHRH analogs and VPAC(1)-R receptors in gastrointestinal smooth muscles, which may influence bowel motility. These mechanisms remain under investigation.

Cardiac Studies

Preliminary murine studies indicate that modified GRF 1-29 peptides may support cardiac tissue repair and improve ejection fraction following heart injury, suggesting a possible cardiovascular benefit.

Combination Protocols

Due to its shorter activity, CJC-1295 (No DAC) is often paired with growth hormone secretagogues like Ipamorelin. These act on ghrelin receptors, and when combined with GHRH analogs, may synergistically elevate GH secretion through dual receptor activation on pituitary cells.

Disclaimer

All products offered by America1stPeptides.com are intended strictly for laboratory and scientific research purposes only. These products are not approved by the FDA, are not medicines or supplements, and are not sold for human consumption, medical treatment, or veterinary use. Any discussion of potential benefits is based solely on preclinical findings.