Semax 10mg

Semax Overview
Semax, originally developed in Russia, has been extensively studied for its potential in supporting neurological and cognitive health. Research suggests benefits in stroke recovery, cognitive decline, dementia, and optic nerve inflammation. It has also demonstrated antidepressant and anxiolytic properties, as well as potential immune-modulating effects. Findings indicate that Semax increases brain-derived neurotrophic factor (BDNF) levels in the central nervous system, along with serotonin and dopamine, which may contribute to its neuroprotective and mood-regulating effects.

Semax Structure

Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Formula: C37H51N9O10S
Molecular Weight: 813.92 g/mol
CAS Number: 80714-61-0
Synonyms: Pro-Gly-Pro-ACTH
Source: PubChem

What Is Semax?
Semax is a synthetic analogue of adrenocorticotropic hormone (ACTH), derived from amino acids 4–10 of the ACTH fragment. Its unique structure enables activity in the central nervous system, where it has been linked to enhanced gene expression, neuroplasticity, and modulation of neurotransmitter systems.

Semax and Brain Function
Functional MRI studies reveal that Semax activates the brain’s default mode network, a system associated with environmental monitoring, attention, and social cognition. This may enhance resting attentiveness and cognitive flexibility, potentially improving problem-solving, memory, and creativity.

Semax in Stroke and Neuroprotection
Preclinical and clinical studies suggest that Semax stimulates gene expression tied to vascular function, blood cell formation, and neuroprotection. In stroke models, it promotes neuronal survival, stabilizes mitochondrial function, and supports nutrient delivery to brain tissue. Clinical use in rehabilitation has been associated with accelerated recovery, higher motor function, and increased plasma BDNF levels.

Gene Expression and Learning
Research in animal models indicates that Semax rapidly influences gene expression in both the hippocampus and frontal cortex—key regions for learning, memory, and executive function. These effects are linked to elevated NGF and BDNF levels, supporting theories that Semax may enhance neuroplasticity and improve learning efficiency.

Cognitive and Emotional Effects
Studies suggest that ACTH and its analogues, including Semax, protect learning and memory in models of epilepsy and may serve as nootropic agents. Additional research highlights antidepressant potential, with BDNF stimulation considered a key factor in regulating brain function during depression. This mechanism may complement traditional SSRIs by accelerating neurogenesis and mood stabilization.

Safety and Use
In preclinical models, Semax shows good bioavailability, low toxicity, and minimal side effects. However, human clinical data remain limited. At America1stPeptides.com, Semax is provided exclusively for laboratory and scientific research purposes.

Disclaimer

All products offered by America1stPeptides.com are intended strictly for laboratory and scientific research purposes only. These products are not approved by the FDA, are not medicines or supplements, and are not sold for human consumption, medical treatment, or veterinary use. Any discussion of potential benefits is based solely on preclinical findings.

Referenced Citations

1. Lebedeva IS et al., Bull. Exp. Biol. Med., 2018.

2. Mars RB et al., Front. Hum. Neurosci., 2012.

3. Medvedeva EV et al., BMC Genomics, 2014.

4. Gusev EI et al., Zh. Nevrol. Psikhiatr., 2018.

5. Agapova TI et al., Mol. Genet. Mikrobiol. Virusol., 2008.

6. Scantlebury MH et al., Neurosci. Lett., 2017.

7. Deltheil T et al., Neuropharmacology, 2008.

8. Ivanov A et al., Bull. Exp. Biol. Med., 2017.

9. Bobyntsev II et al., ResearchGate, 2015.